Fig. 7: CircZNF566 promotes HCC progression via TDO2. | Cell Death & Disease

Fig. 7: CircZNF566 promotes HCC progression via TDO2.

From: Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression

Fig. 7

a Pearson correlation analysis indicated a significantly positive correlation between the levels of circZNF566 and TDO2 in 57 pairs of HCC tissues and matched normal liver tissues. b Relative TDO2 expression was detected in HCC cells transfected with shTDO2, TDO2 overexpression plasmid or NC and si-circZNF566, circZNF566, or NC. b Relative luciferase activities were detected in HCC cells transfected luciferase reporter plasmids expressing the WT TDO2 mRNA 3′-UTR. d, e The effects of circZNF566 and TDO2 on the protein expression of Bcl-2, N-cadherin, E-cadherin, Ki67, Caspase, and Vimentin were detected by WB. f, g The effects of circZNF566 and TDO2 on HCC cells migration, invasion, and proliferation in HCC cell lines were evaluated by transwell migration and invasion, colony formation and CCK-8 assays. All data are from three independent experiments and are presented as the means ± SEM or representative of three independent experiments with similar results (*p < 0.05, **p < 0.01, ***p < 0.001).

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