Fig. 6: NOX1 silencing blocks ox-LOL-induced phenotypic alteration in HASMCs. | Cell Death & Disease

Fig. 6: NOX1 silencing blocks ox-LOL-induced phenotypic alteration in HASMCs.

From: LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype

Fig. 6

a CCK-8 measured proliferation curves of HASMCs treated by ox-LDL, or transfected with siANRIL and siNOX1. b Cellular ROS levels of HASMCs after by ox-LDL, or transfected with siANRIL and siNOX1, as detected by flow cytometry. c, d Representative images c and quantification results d of HASMCs with ox-LDL treatment and ANRIL or NOX1 silencing, as showed in transwell migration assay. e, f mRNA e and protein f levels of NOX1 and OPN in HASMCs with ox-LDL inducing and ANRIL or NOX1 silencing.

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