Fig. 6: High BIK mRNA and protein levels predict poor survival of ER-positive breast cancer patients in multiple datasets. | Cell Death & Disease

Fig. 6: High BIK mRNA and protein levels predict poor survival of ER-positive breast cancer patients in multiple datasets.

From: BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer

Fig. 6

a A Tukey box and whisker plot depicting BIK gene expression values in non-TNBC and TNBC patients obtained from the publicly available dataset GSE65194. The horizontal line inside the box represents the median. Student′s two-tailed t-test was performed to determine statistical significance between the two groups. b Kaplan–Meier survival curves depicting disease-free survival outcomes of a total of 287 ER-positive patients stratified into BIK-high and -low groups based on BIK mRNA levels in tumors. The hazard ratio (HR) value of greater than 1.0 estimates the predicted risk of poor prognosis. P-value was calculated using the log-rank test. c Kaplan–Meier survival curves depicting disease-free survival outcomes of a total of 383 TNBC patients stratified into BIK-high and -low groups based on BIK mRNA levels in tumors. d, e Kaplan–Meier survival curves depicting five-year disease-free or overall survival outcomes of a total 152 of patients stratified in ER-positive antiestrogen treated vs. ER-negative groups. Survival outcomes were calculated based on BIK protein levels in tumor cores. The hazard ratio (HR) value of greater than 1.0 estimates the predicted risk of poor prognosis. P-value was calculated using the log-rank test.

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