Fig. 5: SLNB treatment modulates ASC’s transcriptome and triggers ASCs’ responses to interferon. | Cell Death & Disease

Fig. 5: SLNB treatment modulates ASC’s transcriptome and triggers ASCs’ responses to interferon.

From: Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages

Fig. 5

LPS-primed ASCs were treated with SC3, SLN3, SCB, and SLNB respectively for 2 h. a RNA-seq heat map for ASCs exposed to SC3, SLN3, SCB, and SLNB respectively (n = 3). The heat map showed 114 significantly up-regulated genes (q < 0.001) in SLNB-treated ASCs compared to SCB-treated and SLN3-treated ASCs. Red (12) to blue (0) were ranked by values of log2(value of gene expression+1). b The significant KEGG pathways (q < 0.05) of the genes in a. c Gene Ontology analysis of the genes in a showing the biological process for SLNB treatment (q < 0.05). ASCs adipose tissue-derived mesenchymal stem cells, SC3 supernatant collected from 3T3 cells, SLN3 supernatant collected from LPS/NIG-treated 3T3 cells, SCB supernatant collected from BMDMs, SLNB supernatant collected from LPS/NIG-treated BMDMs, KEGG Kyoto Encyclopedia of Genes and Genomes, Num number.

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