Fig. 1: HIF-1α is increased in human and mouse knee articular cartilage.
From: Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy
a Representative X ray images of normal and osteoarthritis patients. b The protein expression of HIF-1α in human chondrocytes derived from normal and osteoarthritis patients. c Quantification of HIF-1α by immunoblots. d, e The expression of HIF-1α from hypoxia treated mouse chondrocytes was analyzed by western blot. f, g Quantification of HIF-1α immunoblots. h–k Bioinformatic histogram, Volcano Plot, KEGG and Heatmap analyses of the key molecules and signaling pathways differentially regulated in mouse chondrocytes treated with hypoxia condition (1% pO2) for 24 h based on transcriptome analysis. All data represent mean ± S.D. (n = 6). **P < 0.01, *P < 0.05.
