Fig. 7: DMOG ameliorates OA development in DMM mouse model.
From: Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy
Osteoarthritis mouse model was established by surgical destabilization of the medial meniscus and 8-week injuryknee jointwere takenX-ray, RT-qPCR and stained with H&E, Alcian Blue, Safranin Oandimmunohistochemistry staining. a, b The expression of HIF-1α was evaluated by immunohistochemistry staining. c Digital X-ray image of mouse knee joints in different groups. d Representative HE, S-O, Alcian Blue staining of cartilage in each group at 8-week after surgery. e OARIS scores of cartilage in each group. f, g The expression of LC3-II and Cleaved-caspase3 were evaluated by immunohistochemistry staining. All data represent mean ± S.D (n = 6). **P < 0.01, *P < 0.05.
