Fig. 5: RanBP2/RanGAP1 complex may act as E3 involved in DAXX SUMOylation.

a–c Volcano plot of differentially expressed genes (DEGs) of DAXX, SUMO-2, and SUMO-3. Red spots represent upregulated DEGs and green spots represent downregulated DEGs. d Venn diagram illustrating the number of upregulated DEGs in three groups. e, f Functional enrichment analysis of 389 signature DEGs. g STRING database analysis of DAXX, SUMO-2/3, RanBP2, and RanGAP1. h, i Correlations among DAXX, SUMO-2/3, RanBP2, and RanGAP1.