Fig. 6: Echinatin suppresses the growth of ESCC tumor xenograft in nude mice. | Cell Death & Disease

Fig. 6: Echinatin suppresses the growth of ESCC tumor xenograft in nude mice.

From: Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis

Fig. 6

The nude mice bearing KYSE270-derived tumor xenografts were orally administrated with echinatin (20 mg/kg or 50 mg/kg) every 2 days (n = 6 per group), whereas the control group received the vehicle only. a Tumor curves showed that echinatin significantly suppressed the growth of tumor xenografts. b Expression levels of AKT, p-AKT, mTOR, p-mTOR and LC3 in the tumors from mice treated with echinatin or vehicle were detected by Western blot. c Body weight of nude mice during the experimental period. d Hematoxylin and eosin (H&E) staining of lung, liver, and kidney specimens collected from mice of the treatment and control groups. e Comparison of serum ALT and AST level between echinatin-treated and control groups. Bars, SD; ***P < 0.001.

Back to article page