Fig. 2: The function and possible mechanisms of ferroptosis in various liver injury.
From: The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?
Dysregulation of ferroptosis has been linked to various liver diseases and its modification may provide a hopeful and attractive therapeutic prospect. Indeed, targeting ferroptosis may prevent the pathophysiological progression of several liver injuries, such as acute liver failure, alcoholic liver disease, NAFLD and immune-mediated hepatitis. The underpinning mechanisms include interplay between antiferroptotic action and other bioactivities including anti-inflammatory, antioxidant action and regulation of immunogenic response. APAP, acetaminophen, GSH, glutathione, GPx4, glutathione peroxidase 4, ROS, reactive oxygen species, HMGB1, high mobility group protein B1, HO-1, heme oxygenase-1, Nrf2, nuclear factor erythroid 2-related factor 2, SIRT1, Sirtuin1, IDO1, indoleamine 2,3-dioxygenase 1, iNOS, inducible nitric oxide synthase, RNS, reactive nitrogen species, Cav-1, Caveolin-1.
