Fig. 3: The dual role of ferroptosis in distinct hepatic entities.
From: The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?
The cornerstone in the fibrogenic process is the activation of HSC. When driven by hepatic damage elements, quiescent HSC transdifferentiate into contractile myofibroblast capable of matrix production, subsequently resulting in fibrosis. Recent studies have found that modulation of ferroptosis might serve as anti-fibrotic therapy. Moreover, ferritinophagy-mediated HSC ferroptosis was also responsible for anti-fibrosis efficacy. HSC, hepatic stellate cell, APAP, acetaminophen, HO-1, heme oxygenase-1.
