Table 2 The function and mechanisms of ferroptosis in fibrosis.

From: The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?

Model

Ref.

Compound/target

Effect

Fibrogenic marker

Mechanism

CCl4-induced fibrosis

93

MgIG

Induction of HSC ferroptosis

α-SMA, collagen1, fibronectin, desmin

TGF-βR1, PDGF-βR

HO-1↑

CCl4-induced fibrosis

94

Artemether

Induction of HSC ferroptosis

α-SMA, collagen, fibronectin

PDGF-βR, EGFR↓p53↑

BDL-treated fibrosis

95

ELAVL1

Activation of HSC ferritinophagy/ferroptosis

ACTA2, COL1A1

BECN1 mRNA stability↓

BDL-treated fibrosis

96

ZFP36

Inhibition of HSC autophagy/ferroptosis

ACTA2, COL1A1

ATG16L1 mRNA decay↓

CCl4-induced fibrosis

97

Artesunate

Activation of HSC ferritinophagy/ferroptosis

α-SMA, collagen1, fibronectin

LC3-II↑ p62, FTH1, NCOA4↓

  1. CCl4 carbon tetrachloride, MgIG magnesium isoglycyrrhizinate, HSC hepatic stellate cell, α-SMA alpha-smooth muscle actin, HO-1 heme oxygenase-1, BDL bile duct ligation, ELAVL1 ELAV like RNA-binding protein 1, COL1A1 collagen type I alpha 1, BECN1 beclin 1, FN1 fibronectin 1, NCOA4 nuclear receptor coactivator 4, LC3 microtubule-associated protein light chain 3, FTH1 ferritin heavy chain.
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