Fig. 7: Microglial depletion reduces neuronal survival and exacerbates axonal dieback. | Cell Death & Disease

Fig. 7: Microglial depletion reduces neuronal survival and exacerbates axonal dieback.

From: Depletion of microglia exacerbates injury and impairs function recovery after spinal cord injury in mice

Fig. 7

a, b Representative images taken around the lesion epicenter at 30 dpi immunostained for NeuN (green) and DAPI (blue). c Quantification of the number of NeuN+ cells in the spinal cord from control and PLX3397-treated mice (n = 4 per group) as shown in a and b. d, e Representative sagittal sections of the spinal cord from control and PLX3397-treated mice at 8 weeks after injury. BDA-labeled CST axons are shown in red. Blue represents DAPI immunostaining. White asterisk represents lesion epicenter. f Quantification of axonal dieback distance at 8 weeks post SCI as shown in d and e (n = 4 per group). Data are expressed as mean ± SD. **p < 0.01, ***p < 0.001. Scale bars: a, b, in b 50 µm; d, e, in e 200 µm.

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