Fig. 7: LTSCCAT has a significant impact on tumor development and metastasis in vivo. | Cell Death & Disease

Fig. 7: LTSCCAT has a significant impact on tumor development and metastasis in vivo.

From: LncRNA LTSCCAT promotes tongue squamous cell carcinoma metastasis via targeting the miR-103a-2-5p/SMYD3/TWIST1 axis

Fig. 7

a Morphology of footpad transplanted tumors in mice inoculated with LTSCCAT overexpression CAL27 and negative control CAL27 cells. b Comparison of the size of transplanted tumors in overexpressed LTSCCAT group and control group over time. c The average weight of transplanted tumors in the overexpressing LTSCCAT group was greater than that in the control group. d The lateral axillary lymph node morphology of the inoculated LTSCCAT overexpression group and control group mice. e The expression level of LTSCCAT in the LTSCCAT overexpression group of transplanted tumors was higher than that in the control group. f The size of axillary lymph nodes in the LTSCCAT overexpression group was greater than that of the control group. g Immunohistochemistry showed the expression of E-cadherin in transplanted tumors. h Immunohistochemistry showed the expression of vimentin in transplanted tumors. i Immunohistochemistry showed the expression of Twist1 in transplanted tumors. j Immunohistochemistry showed the expression of SMYD3 in transplanted tumors. k Proposed model of the role of LTSCCAT in TSCC metastasis.

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