Table 1 Peripheral blood counts from 7- to 10-week-old (Caspase-8fl/fl Mlklfl/fl (wild-type), Caspase-8Pf4Δ/Pf4Δ, MlklPf4Δ/Pf4Δ, Caspase-8Pf4Δ/Pf4Δ MlklPf4Δ/Pf4Δ) female and male mice.
From: The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis
Caspase-8fl/fl Mlklfl/fl (n = 16) | Caspase-8Pf4Δ/Pf4Δ (n = 7) | MlklPf4Δ/Pf4Δ (n = 8) | Caspase-8Pf4Δ/Pf4Δ MlklPf4Δ/Pf4Δ (n = 8) | |
|---|---|---|---|---|
Platelets, × 106/mL | 1066 ± 176.9 | 968 ± 186 | 1087 ± 103.6 | 1138 ± 118.2 |
MPV, femtoliters | 5.4 ± 0.4 | 4.9 ± 0.1∗∗ | 5.8 ± 0.3* | 5.6 ± 0.2 |
PDW, % measurement | 50.7 ± 5.7 | 50.6 ± 7.2 | 49.7 ± 2.1 | 49.9 ± 4.2 |
Hematocrit, % | 50.7 ± 2.1 | 49.8 ± 2.3 | 50.0 ± 0.6 | 51.6 ± 2.0 |
Erythrocytes, × 109/mL | 10.4 ± 0.3 | 10.5 ± 0.5 | 10.1 ± 0.1∗ | 10.5 ± 0.3 |
Leukocytes, × 106/mL | 8.4 ± 1.5 | 9.9 ± 2.2 | 9.7 ± 0.9 | 7.9 ± 1.0 |
Neutrophils, × 106/mL | 0.9 ± 0.6 | 1.1 ± 0.4 | 1.0 ± 0.4 | 0.5 ± 0.1 |
Lymphocytes, × 106/mL | 7.1 ± 1.1 | 8.4 ± 2.3 | 8.3 ± 0.9 | 7.0 ± 0.9 |
Monocytes, × 106/mL | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
Eosinophils, × 106/mL | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.0 |
