Fig. 4: miR-651-3p endogenous expression and the effect on VM formation in glioma cells. | Cell Death & Disease

Fig. 4: miR-651-3p endogenous expression and the effect on VM formation in glioma cells.

From: HNRNPD interacts with ZHX2 regulating the vasculogenic mimicry formation of glioma cells via linc00707/miR-651-3p/SP2 axis

Fig. 4

A Expression levels of miR-651-3p in glioma tissues. Data are presented as the mean ± SD (n = 9, each group). **P < 0.01 vs. NBTs group; #P < 0.05 vs. LGGTs group. B Expression levels of miR-651-3p in glioma cells. Data are presented as the mean ± SD (n = 3, each group). **P < 0.01 vs. HA group. C–E CCK-8 assay, transwell, and three-dimensional culture were applied to evaluate the proliferation, migration, invasion, and tube formation effect of miR-651-3p on U87 and U251 cells. Representative images and corresponding statistical plots are shown. The scale bar represents 50 µm. F Protein levels of MMP2, MMP9, and VE-cadherin regulated by miR-651-3p in U87 and U251 cells. Data are presented as the mean ± SD (n = 3, each group). *P < 0.05, **P < 0.01 vs. pre-NC group; #P < 0.05, ##P < 0.01 vs. anti-NC group.

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