Fig. 5: Ac-DMLD-CMK decreases cisplatin-induced renal pyroptosis in vivo.
From: Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity
A, B Serum creatinine and BUN detected in cisplatin-treated mice before or after Ac-DMLD-CMK pre-treatment. C HE staining of cisplatin-treated mice before or after Ac-DMLD-CMK pre-treatment. Scale bar, 50 μm. D–F Western blot analysis of GSDME and caspase 3 in cisplatin-treated mice before, or after, Ac-DMLD-CMK pretreatment. G, H mRNA expression of kidney injury-related genes and inflammatory-related genes in cisplatin-treated mice before, or after, Ac-DMLD-CMK pretreatment. All data are shown as means ± SD from six independent experiments (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 using one-way ANOVA followed by the Tukey’s method.
