Fig. 7: U0126 and SP600125 alleviate cisplatin-induced renal pyroptosis in vivo.
From: Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity
A, B Western blot analysis of ERK and JNK in kidney tissues from different groups. C, D Serum creatinine and BUN detected in cisplatin-treated mice before or after U0126 and SP600125 pretreatment. E, F mRNA expression of renal injury-related genes in kidney tissues from different groups. G Representative images of HE staining in kidney tissues from different groups. Scale bar, 50 μm. H–J Western blot analysis of GSDME and caspase 3 in cisplatin-treated mice before, or after, Ac-DMLD-CMK pretreatment. All data are presented as mean ± SD from six independent experiments (n = 6). **p < 0.01, ***p < 0.001, ****p < 0.0001 using one-way ANOVA followed by the Tukey’s method.
