Fig. 3: p53 associates and activates ARTS promoter. | Cell Death & Disease

Fig. 3: p53 associates and activates ARTS promoter.

From: p53 induces ARTS to promote mitochondrial apoptosis

Fig. 3

A A schematic of the predicted p53-responsive elements on the promoter or within the intron of ARTS. B p53 induces the expression of a luciferase reporter gene driven by RE1. H1299 cells were transfected with plasmids as indicated in the “Materials and methods” for over 30 h followed by the luciferase assay. C, D p53 associates with RE2, but not RE1, on the ARTS promoter. HCT116p53+/+ cells were prepared for the ChIP-qPCR analysis using the antibodies as indicated.

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