Fig. 7: A schematic for the p53-ARTS interplay in triggering mitochondrial apoptosis. | Cell Death & Disease

Fig. 7: A schematic for the p53-ARTS interplay in triggering mitochondrial apoptosis.

From: p53 induces ARTS to promote mitochondrial apoptosis

Fig. 7

Upon various stress conditions, p53 transcriptionally induces the expression of ARTS, which in turn interacts with and relocates p53 to the mitochondria. The interaction of p53 with Bcl-XL can be enhanced by ARTS, consequently leading to MOMP and apoptosis.

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