Fig. 3: Fgf9 CKO in GABAergic neurons induces neuronal apoptosis. | Cell Death & Disease

Fig. 3: Fgf9 CKO in GABAergic neurons induces neuronal apoptosis.

From: Deletion of FGF9 in GABAergic neurons causes epilepsy

Fig. 3

A EEG recordings of other types of Fgf9 CKO mice associated with GABAergic neurons (CKONestin, CKOVGAT, and CKOVGLUT1) showing spontaneous seizures. B Schematic diagram describes that CKO Fgf9 in many different cell types. CKO mice with epilepsy indicated in red, and no seizure CKO mice indicated in black. C Caspase-3 colocalized with GABAergic neurons (calbindin) in the cortex of CKOVGAT mice by immunostaining. The density of calbindin (1156 ± 45.6 vs 364 ± 22.3, P = 0.0054) or caspase-3 (302 ± 28.1 vs 1324 ± 25.2, P = 0.0063) in the cortex of F/F and CKOVGAT mice. Scale bars, 100 μm. D Western blot analysis demonstrates higher caspase-3 expression in the cortex of CKOVGAT mice than in controls.

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