Fig. 5: ADEs transfer miR-6780b-5p to ovarian cancer cells. | Cell Death & Disease

Fig. 5: ADEs transfer miR-6780b-5p to ovarian cancer cells.

From: Exosomes in ovarian cancer ascites promote epithelial–mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p

Fig. 5

a The expression of miRNA in the exosomes from three ovarian cancer cell lines was compared with that in the cytoplasm, and samples with higher expression were selected. A total of 25 miRNAs were expressed in aggressive SKOV3-ip1 and HEYA8 cells but not in the less-invasive A2780 cells. b Thermograms of the seven miRNAs in ovarian cancer cells with the highest expression among the 25 miRNAs. c qRT-PCR was performed to detect the expression of the seven miRNAs in A2780 and CAOV3 cells treated with #7 or #27 ADEs. (miR-1825, miR-122-5p, and miR-4484 are not shown because their CT values were greater than 30). d Venn diagram of the downstream target genes of miR-6780b-5p, which were predicted with three common miRNA prediction websites: TargetScan, miRDB and RNA22. e GO (gene function annotation) analysis of the target genes of miR-6780b-5p. f KEGG analysis of the possible target genes of miR-6780b-5p.

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