Fig. 3: MMP3 is essential for GBP5-driven cell proliferation and invasion.
From: GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway
A Immunoblot analysis of p-Src, p-ERK1/2, and MMP3 in U87-C1, U87-GBP5, U251-C1, and U251-GBP5 cells. GAPDH was used as loading control. B Immunoblot analysis of p-Src, p-ERK1/2, and MMP3 in SNB19shGFP and SNB19shGBP5 cells. GAPDH was used as loading control. C Immunoblot analysis of MMP3 in U87-GBP5 cells with or without MMP3 silencing with siRNA. D Effect of MMP3 knockdown on the GBP5-driven cell proliferation. ***p < 0.001. n = 3. E Effect of MMP3 knockdown on the GBP5-driven cell invasiveness by the matrigel transwell assay. Invasion index = OD570 of invaded cells in treatment groups/OD570 of invaded cells in control groups. **p < 0.01. NC = not statistically significant. n = 3.
