Fig. 2: The formation process of ElciRNA and ecircRNA, including exon-skipping, intron-pairing, and RBP pairing. | Cell Death & Disease

Fig. 2: The formation process of ElciRNA and ecircRNA, including exon-skipping, intron-pairing, and RBP pairing.

From: CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms

Fig. 2

1. Exon-skipping: the upstream exon and the downstream exon are covalently bonded to form an RNA lariat containing several exons and introns.The RNA lariat is spliced again, and the intron is removed to form ecircRNA or EicirRNA. 2.Intron-pairing: the two introns flanking circRNA have complementary structures. The splice sites are brought close by pairing and binding, and the introns are removed to form ecircRNA or EicirRNA. 3. RBP pairing: RBP binds upstream and downstream introns to form a bridge between the introns, and then remove the introns to produce ecircRNA or EicirRNA.

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