Table 1 Some important circRNAs in the digestive system.
From: CircRNAs: a new target for the diagnosis and treatment of digestive system neoplasms
Disease | Dysregulation | CircRNA | miRNA | Biological functions in cancer |
|---|---|---|---|---|
Esophageal cancer | Upregulated | circ_100876 | - | Promotion |
ciRS-7 | miR-876-5p、miR-7 | Promotion | ||
circ-PRKCI | miR-3680-3p | Promotion | ||
circ_0003340 | miR-564 | Promotion | ||
circLPAR3 | miR-198 | Promotion | ||
hsa_circ_0012563 | - | Promotion | ||
hsa_circ_0004771 | miR-339-5p | Promotion | ||
hsa_circ_0006948 | miR-490-3p | Promotion | ||
circ_0000654 | miR-149-5p | Promotion | ||
hsa_circ_0030018 | miR-599 | Promotion | ||
circGSK3β | - | Promotion | ||
cZNF292 | miR-206 | Promotion | ||
circPVT1 | miR-4663 | Promotion | ||
hsa_circ_0006168 | miR-100 | Promotion | ||
hsa_circ_0000337 | miR-670-5p | Promotion | ||
circ-DLG1 | - | Promotion | ||
hsa_circ_0067934 | - | Promotion | ||
hsa_circ_0006948 | - | Promotion | ||
Downregulated | circ-Foxo3 | miR-23a | Inhibition | |
circ-ITCH | miR-7、miR-17、miR-214 | Inhibition | ||
circ0043898 | - | Inhibition | ||
circ-SMAD7 | - | Inhibition | ||
Gastric cancer | Upregulated | circHIPK3 | miR-124、miR-29b | Promotion |
ciRS-7 | miR-7 | Promotion | ||
circPVT1 | miR-125 | Promotion | ||
circPDSS1 | miR-186-5p | Promotion | ||
circ_001569 | miR-145 | Promotion | ||
circ_0023642 | - | Promotion | ||
circ-SFMBT2 | miR-182-5p | Promotion | ||
circNF1 (hsa_circ_0042881) | miR-16 | Promotion | ||
Downregulated | circ-KIAA1244 | - | Inhibition | |
circRNA_100269 | miR-630 | Inhibition | ||
circYAP1 | miR-367-5p | Inhibition | ||
circLARP4 | miR-424-5p | Inhibition | ||
circ-ZFR | miR-130a、miR-107 | Inhibition | ||
circFAT1(e2) | miR-548g | Inhibition | ||
circ_0027599 | miR-101 | Inhibition | ||
hsa_circ_0003159 | miR-223-3p | Inhibition | ||
Pancreatic cancer | Upregulated | circ_100782 | miR-124 | Promotion |
hsa_circ_0007334 circRNA_0007534 ciRS-7 | hsa-miR-144-3p、 hsa-miR-577 miR-625、miR-892b miR-7 | Promotion Promotion Promotion | ||
Hepatocellular carcinoma | Upregulated | hsa_circ_100338 | miR141-3p | Promotion |
circ_104075 | miR-582-3p | Promotion | ||
has_circ_0078710 | miR-31 | Promotion | ||
circ_0067934 | miR-1324 | Promotion | ||
circ-DB hsa_circRNA_104348 circRNA-100338 | miR-34a miR-187-3p- | Promotion Promotion Promotion | ||
circRNA Cdr1as | miR-1270 | Promotion | ||
circ_0000502 | miR-124 | Promotion | ||
hsa_circ_103809 | miR-377-3p | Promotion | ||
circ-104718 | miR-218-5p | Promotion | ||
Downregulated | cric MTO1 | miR-9、miR-9-5p | Inhibition | |
circ-5692 | miR-328-5p | Inhibition | ||
hsa_circ_0004018 | miR-30e-5p、miR-626 | Inhibition | ||
hsa_circ_0005986 | miR-129-5p | Inhibition | ||
hsa_circ_0001649 | - | Inhibition | ||
Cholangiocarcinoma | Upregulated | circRNA CDR1as | miR-641 | Promotion |
circ_0005230 | miR-1238、miR-1299 | Promotion | ||
Downregulated | hsa_circ_0001649 | - | Inhibition | |
Colorectal cancer | Upregulated | hsa_circ_0055625 | miR-106b | Promotion |
circ-ACAP 2 | miR-21-5p | Promotion | ||
circ100290 | miR-516b | Promotion | ||
circ_001569 circ-133 | miR-145 miR-133a | Promotion Promotion | ||
hsa_circ_0004585 | - | Promotion | ||
hsa_circ_102958 | miR-585 | Promotion | ||
circ_101951 | - | Promotion | ||
circ_0060745 | miR-4736 | Promotion | ||
circ_0001946 circRNA_0000392 | miR-135a-5p miR-193a-5p | Promotion Promotion | ||
circ_100876 | miR-516b | Promotion | ||
Downregulated | hsa_circ_103809 | miR-532-3p | Inhibition | |
circ_0026344 | miR-21、miR-31 | Inhibition | ||
circDDX17 | - | Inhibition |
