Fig. 1: MPL was involved in differentiation arrest of CML cells. | Cell Death & Disease

Fig. 1: MPL was involved in differentiation arrest of CML cells.

From: Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy

Fig. 1

A MPL expression levels of CML samples and their normal controls in GEO accession including GSE13159 (nnormal = 74, nCML = 76), GSE47927(nnormal = 15, nCML = 52). B MPL expression levels and volcano plot of differential gene profiles between normal (n = 4) and CML (n = 8) CD34+ quiescent cells (GSE24739). Criteria to filter DEGs were absolute log2FC >1 & P value <0.05 (as the solid lines showed), the high-threshold to shrink DEGs was defined as absolute log2FC >2 & P value <0.01 (as the dashed lines showed). MPL was labeled in the volcano plot. C GSEA showing negative enrichment of JAK/STAT, MAPK pathways gene signatures. Genes were ranked by log2FC. D Volcano plot of correlations between MPL and the other detected genes in CML samples (GSE13159, n = 76). X-axis represented the Pearson coefficients and the Y-axis showed negative log10 of the P values. The correlations between MPL and three MK marker genes, including ITGA2B, GP1BA, and ITGB3, were labeled in the volcano plot and further visualized by correlation plots (E–G). Error bars indicated mean ± standard error of the mean (SEM) (P values: two-tailed Student’ s t test; *P <0.05, **P <0.01, ***P <0.001).

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