Fig. 6: SDF-1 induces EMT of lung ADC cells via CXCR4/β-catenin/PPARδ signalling. | Cell Death & Disease

Fig. 6: SDF-1 induces EMT of lung ADC cells via CXCR4/β-catenin/PPARδ signalling.

From: Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/β-catenin/PPARδ signalling

Fig. 6

a, b The expression of CXCR4 expression was detected using western blotting in several lung ADC cell lines. Compared with control cells (b), higher CXCR4 expression was observed in A549 and SPCA-1 cells (a), and lower CXCR4 expression was observed in CXCR4 knockdown cells. c Western blotting was used to detect CXCR4, β-catenin, PPARδ and EMT-related proteins (vimentin, N-cadherin, Slug, and E-cadherin) in A549 and SPCA-1 cells. d Transwell analysis showed that CXCR4 knockdown, or inhibition of β-catenin and PPARδ eliminated the invasion induced by SDF-1; scale bar: 200 μm. Data are representative images and numerical data are represented as the mean ± SD of each group of cells from three separate experiments. *p < 0.05.

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