Fig. 4: The Figure shows the 3D model of the WW domain of NEDD4 in complex with the SARS- CoV-2 Spike protein.
From: Inhibition of HECT E3 ligases as potential therapy for COVID-19
The WW domain is displayed as a ribbon model, with the interface residue side-chains in gray. The Spike protein is displayed as a ribbon model, and the side-chains of its interface residues are shown in light blue. The Arg843–Asp215 residues are in close proximity and favor a stronger interaction between the variant WW domain and Spike with respect to the wt domain.
