Table 1 HECT genes variants in a cohort of 130 SARS-CoV-2 positive patients (MAF < 0.01 in GnomAD v2.1.1; in bold p < 0.05).

From: Inhibition of HECT E3 ligases as potential therapy for COVID-19

Gene	Genetic form	Genotype	dbSNP	Consequence	AF GnomAD	Gender	Age [years]	p-value	Outcome
HECW1	Known	A1332T/WT	rs200973212	missense	0.0000161	M	54	0.0114	Survived
	Known	E502Q/WT	rs61756576	missense	0.0025630	M	83	0.5801	Deceased
	Known	N1265S/WT	rs200912368	missense	0.0017820	F	50	0.4656	Survived
HECW2	Known	S559G/WT	rs779373864	missense	0.0000085	M	59	0.0072	Survived
	Known	N417S/WT	rs138998510	missense	0.0005529	M	54	0.0791	Survived
	Known	A537P/WT	rs750339715	missense	0.0000121	F	93	0.0092	Deceased
NEDD4	Known	N888K/WT	rs759199057	missense	0.0000119	M	59	0.01	Survived
	Known	G451A/WT	rs60811367	missense	0.0017470	M	54	0.0013	Survived
	Known	G451A/WT	rs60811367	missense	0.0017470	M	39	0.0013	Deceased
	Known	I1237T/WT	rs373718024	missense	0.0003550	M	47	0.0159	Deceased
	Known	R877Q/WT	rs201295772	missense	0.0000958	M	83	0.03176	Deceased
	Known	I843R/WT	rs375088434	missense	0.0000199	F	77	0.0091	Deceased
	Known	T727I/WT	rs61754989	missense	0.0036830	F	72	1	Deceased
	Known	D129N/WT	rs150886795	missense	0.0002875	M	61	0.1233	Deceased
	Known	S29R/WT	rs115484917	missense	0.0026250	M	39	0.1555	Deceased
NEDD4L	Known	c.698C>T/WT	rs202231187	missense	0.0039100	M	73	1	Survived
	Known	c.1258-5A>C/WT	rs768158353	splicing	0.0000853	M	64	0.0141	Deceased
	Known	c.698C>T/WT	rs202231187	missense	0.0039100	M	54	1	Deceased
SMURF1	Known	R564Q/WT	rs182340234	missense	0.0000199	F	52	0.0068	Survived
SMURF1	Known	T223M/WT	rs371859465	missense	0.0000805	F	80	0.022	Survived
SMURF2	Known	G10E/WT	rs866321574	missense	0.0061730	F	36	0.1166	Survived
	Known	G10E/WT	rs866321574	missense	0.0061730	M	73	0.1166	Deceased
	Known	I142V/WT	rs145845053	missense	0.0005564	M	14	0.1281	Survived
WWP1	Known	c.2395-4C>T/WT	rs188228045	splicing	0.0000040	F	89	1	Deceased
	Known	c.540-5T>C/WT	rs187132881	splicing	0.0023640	F	83	0.5073	Deceased
	Known	c.1836G>A/WT	rs150841032	splicing	0.0002012	M	76	0.1019	Deceased
WWP2	Known	R803C/WT	rs747018644	missense	0.0000043	M	54	0.0049	Survived
WWP2	New	M114I/WT	rs377573067	splicing	/	F	83	/	Deceased

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Table 1 HECT genes variants in a cohort of 130 SARS-CoV-2 positive patients (MAF < 0.01 in GnomAD v2.1.1; in bold p < 0.05).

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