Fig. 7: USP53 levels decrease in an osteoporosis mouse model. | Cell Death & Disease

Fig. 7: USP53 levels decrease in an osteoporosis mouse model.

From: Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

Fig. 7

a Sham or ovariectomy (OVX) surgery was performed on 6-week-old female mice. Two months later, femoral trabecular bone mass was assessed by μCT. Scale bars, 50 μm. b Serum levels of the c-terminal telopeptide (CTX)-1 in sham and OVX mice. c Immunohistochemistry analysis of USP53 (phycoerythrin [PE]; red fluorescence) and OCN (fluorescein isothiocyanate [FITC]; green fluorescence) with DAPI counterstaining in sham-operated and OVX mice (left). Quantification of IHC analysis (right). Scale bars, 20 μm. Results are means ± SDs. **P < 0.01 by an unpaired two-tailed Student’s t-test. n = 5–10 per group. d Diagram showing the molecular mechanism through which FBXO31 and USP53 regulate the Wnt signaling mediator, β-catenin, during the osteogenic differentiation of hBMSCs.

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