Fig. 1: Gab2 is increased in adipose tissue in HFD-fed mice and deletion of Gab2 protects against HFD-induced obesity. | Cell Death & Disease

Fig. 1: Gab2 is increased in adipose tissue in HFD-fed mice and deletion of Gab2 protects against HFD-induced obesity.

From: Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice

Fig. 1

A Relative mRNA level of Gab2 in brown adipose tissue (BAT), inguinal (iWAT), and epididymal (eWAT) white adipose tissue from mice fed with a standard diet (SD) or a high-fat diet (HFD) for 12 weeks detected by RT-qPCR. The results were normalized with S18 mRNA levels. B Left panel: representative blots of Gab2 protein expression in BAT (top), iWAT (middle), and eWAT (bottom) of mice described in A detected by immunoblotting analysis; Right panel: the relative grayscale values of Gab2 protein blots, β-Tubulin protein was measured as a loading control. C–F Bodyweight gain from weeks 6 to 18 (C), food intake (D), fat mass (E), and lean mass (F) of Gab2 KO and WT mice fed with SD and HFD diet for 12 weeks. The data are presented as mean ± SD from at least six mice in each group. Statistical difference is indicated: *P < 0.05; **P < 0.01; ***P < 0.001.

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