Fig. 6: The combination of CPX and BTZ promotes inhibition of GBM cell growth in vivo. | Cell Death & Disease

Fig. 6: The combination of CPX and BTZ promotes inhibition of GBM cell growth in vivo.

From: Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Fig. 6

A–C Tumor-bearing nude mice of U251 cells (n = 5) were injected intraperitoneally twice daily for 14 consecutive days with physiological saline (0.9% NaCl), CPX (5 mg/kg), BTZ (0.4 mg/kg), or a combination of CPX and BTZ (5 mg/kg and 0.4 mg/kg, respectively). Mice were sacrificed on day 14, and their tumors were harvested and weighed. The dissected tumors are shown (A). Tumor volumes (B) and tumor weights (n = 5) of dissected tumors (C) from mice treated with 0.9% NaCl, CPX, BTZ, or a combination of CPX and BTZ. Data represent mean ± SD (*p < 0.05; **p < 0.01; ***p < 0.001). D, E Expression levels of p65, p-p65, IκBα, p38, p-p38, JNK, and p-JNK in tumor tissue lysates were examined by immunoblotting analysis. F Proposed mechanistic model of synergistic effects of CPX and BTZ inhibiting GBM cell growth, migration, and invasion.

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