Fig. 5: CTRP12-induced upregulation of LXRα, ABCA1, and ABCG1 is mediated by miR-155-5p. | Cell Death & Disease

Fig. 5: CTRP12-induced upregulation of LXRα, ABCA1, and ABCG1 is mediated by miR-155-5p.

From: CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway

Fig. 5

A THP-1 macrophages were treated with 50 µg/mL ox-LDL for 48 h and then transfected with PBS, LV-NC, or LV-CTRP12 for 72 h, followed by detection of miR-155-5p expression using qRT-PCR. B–D THP-1 macrophages were loaded with 50 µg/mL ox-LDL for 48 h, transfected with miR-155-5p mimic for another 48 h and then transduced with LV-CTRP12 for 72 h. The mRNA and protein levels of LXRα, ABCA1, and ABCG1 were detected by qRT-PCR and western blot, respectively. Data are represented as the mean ± SD from three independent experiments. *P < 0.05, **P < 0.01, ****P < 0.0001.

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