Fig. 7: CTRP12 inhibits atherosclerosis in apoE−/− mice. | Cell Death & Disease

Fig. 7: CTRP12 inhibits atherosclerosis in apoE−/− mice.

From: CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway

Fig. 7

A–C Western diet-fed apoE−/− mice were injected via the tail vein with PBS, LV-NC, or LV-CTRP12 (n = 15 in each group). A Analysis of CTRP12 expression in the aortas by western blot (n = 10). B The plaques (green arrows) in the aortic arch under a stereoscopic microscope (n = 10); C Cryosections of the aortic root were stained with HE, Oil Red O, or Masson, followed by quantification of lesion area, lipid accumulation and collagen contents using Image-Pro Plus 7.0 software (n = 10). Scale bar = 100 μm. Data are represented as the mean ± SD. ****P < 0.0001; ns not significant.

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