Fig. 1: miR-150-5p/3p are downregulated in OC.
From: FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop
A Dysregulated miRNAs in OC compared with the corresponding control in GSE71477, GSE106817, and GSE61485 datasets (FC <0.8 or >1.25, P < 0.025). B–D Expression of miR-150-5p and miR-150-3p was significantly downregulated in OC compared with those in the endometrium (GSE71477) (B), benign ovarian disease (GSE106817) (C), or normal fallopian tube fimbria (GSE61485) (D). E The levels of miR-150 precursor (mir-150) were also reduced in OC compared with noncancerous ovarian tissues (E-TABM-343). F Kaplan–Meier survival curves for OC patients according to mir-150 expression levels in tumor tissues; significance was calculated using log-rank test. The data are presented as the mean ± s.d. **P < 0.01, ***P < 0.001 by Wilcoxon signed-rank test or Mann–Whitney U-test.
