Fig. 1: Similar morphology, immunophenotype, and frequency between MSCs from patients with active cGVHD, patients without cGVHD and heathy donors. | Cell Death & Disease

Fig. 1: Similar morphology, immunophenotype, and frequency between MSCs from patients with active cGVHD, patients without cGVHD and heathy donors.

From: Wnt/β-catenin signaling mediates the abnormal osteogenic and adipogenic capabilities of bone marrow mesenchymal stem cells from chronic graft-versus-host disease patients

Fig. 1

A Representative morphology of HD-MSCs, no cGVHD-MSCs, and active cGVHD-MSCs. Scale bar = 200 µm. B Representative flow cytometric characterization of cell surface marker expression on MSCs in healthy donors, patients without cGVHD and patients with active cGVHD. Gray-filled histograms depict the expression of CD29, CD44, CD90, and CD105 and the absence of CD19, CD31, CD34, and CD45. Isotypic controls are represented by the open histograms. C Frequency of MSCs in healthy donors, patients without cGVHD, and patients with active cGVHD. D Frequency of MSCs in patients with different severities of cGVHD. HD-MSCs (N = 7), no cGVHD MSCs (N = 33), mild cGVHD-MSCs (N = 8) and morerate/severe cGVHD (N = 25). Black bars in each figure represent the median ± range. NS, not significant.

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