Fig. 1: Bioinformatics analysis demonstrates a key role for KIF18B in the development and progression of PCa.
From: Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells
A Sample dendrogram shows the samples included in this study and trait heatmap shows the distribution of the clinicopathological characteristics among these samples. B Scale independence and mean connectivity demonstrates the best soft threshold was determined as 4. C Cluster dendrogram shows the processes of screening of modules. Each of the modules were determined by dynamic tree cut method first and then merged finally. D Module-trait relationships demonstrate the relationships between the clinicopathological characteristics and selected modules. Pearson coefficient and P value were utilized for screening the interested modules. E The PPI network of genes in magenta modules. KIF20A and KIF4A were the dominant genes in the PPI network. F Nightingale’s Rose diagram demonstrated the co-expression genes with KIF18B. G The heatmaps demonstrated differentially expressed KIF-related genes in PCa. H The expression correlation analyses demonstrated the expression pattern of KIF18B with KIF20A and KIF4A. Spearman coefficient and P value were utilized for evaluating the expression correlation.
