Table 2 Univariate and multivariate Cox regression analyses of risk factors for biochemical recurrence.
From: Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells
Variable | Univariate (coef, HR (95% CI), P value) | Multiple Cox regression (coef, HR (95% CI), P value) |
|---|---|---|
Age (years) | ||
<70 | 1 | 1 |
≥70 | 0.468, 1.593 (1.022, 2.496), 0.040 | 0.3751, 1.455 (0.855, 2.392), 0.1389 |
Prostate volume (cm3) | ||
≤35 | 1 | |
>35 | 0.405, 1.500 (0.934, 2.409), 0.0934 | |
PSA (ng/ml) | ||
<10 | 1 | |
10–20 | 0.700, 2.013 (1.001, 4.049), 0.0500 | |
>20 | 0.425, 1.529 (0.644, 3.630), 0.336 | |
PSAD (ng/ml cm3) | ||
<0.15 | 1 | |
≥0.15 | 0.623, 1.864 (0.588, 5.905), 0.290 | |
Gleason score | ||
<7 | 1 | 1 |
7 | 1.464, 4.324 (2.304, 8.116), <0.001 | 1.021, 2.777 (1.469, 5.247), 0.0017 |
>7 | 1.500, 4.461 (2.194, 9.074), <0.001 | 0.857, 2.355 (1.027, 5.401), 0.0430 |
pT stage | ||
pT2 | 1 | |
pT3a | 0.665, 1.944 (0.956, 3.950), 0.0663 | |
pT3b | 1.884, 6.576 (3.052, 14.171), <0.001 | |
Positive margin | ||
No | 1 | 1 |
Yes | 1.440, 4.222, (2.503, 7.122), <0.001 | 1.015, 2.758 (1.474, 5.167), 0.0015 |
KIF18B | ||
Negative | 1 | 1 |
Positive | 2.1322, 8.433 (3.671, 19.371), <0.001 | 1.882, 6.569 (2.829, 15.255), <0.001 |
