Fig. 1: Low expression of PEDF is correlated with poor prognosis and negatively with LVD in human NPC tissues.
From: PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor
A PEDF staining of tissue microarray by IHC (image magnification, 200×), the tissue microarray contains human nasopharyngeal cancer (22 cases), papilloma (15 cases), polyp (6 cases), hyperplasia, and inflammation (6 cases). The malignant tumor group includes human nasopharyngeal cancer (22 cases). The others (27 cases) are the control group. B The histogram represents the PEDF expression in the tissue microarray quantified by grayscale scanning with Image pro-plus. C LVD in the tissue microarray with D2-40 staining lymphatic tubes (image magnification, 200×) and the statistical graph (D). E The correlation analyses of PEDF expression and LVD in the tissue microarray. F Kaplan–Meier analysis of 3-years overall survival (OS) and G proportion of patients at different lymph node stages in a set of 168 nasopharyngeal cancer patients (n = 168) according to PEDF expression. Scale bars:100 μm (A, C), *p < 0.05, **p < 0.01, the results are presented as mean ± SD.
