Fig. 4: PEDF was negatively correlated with VEGF-C in NPC tissues and cell lines and could inhibit the expression of VEGF-C in vivo. | Cell Death & Disease

Fig. 4: PEDF was negatively correlated with VEGF-C in NPC tissues and cell lines and could inhibit the expression of VEGF-C in vivo.

From: PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor

Fig. 4

A VEGF-C staining in tissue microarray by IHC (image magnification, 200×). B The PEDF and VEGF-C expression in different nasopharyngeal cancer cell lines, S18, S26, 5–8 F, and 6–10B. C–F VEGF-C staining (image magnification, 200×) by IHC (C), IF (D), and western blot (E, each lane represents the sample from an individual mouse) in nasopharyngeal cancer xenografts treated with PBS or rPEDF for 20 days, and the expression of VEGF-C was quantified by grayscale scanning with Image J (F). Scale bars:100 μm (A, C, D), *p < 0.05, the result is presented as mean ± SD.

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