Fig. 2: Characterization of putative SEC23B nuclear localization and export signals.
From: Non-canonical role of wild-type SEC23B in the cellular stress response pathway
A Truncation mutant constructs generated to characterize the bioinformatically top scoring NLS sequences and the single predicted NES sequence. The full-length SEC23B protein (Uniprot Q15437, SC23B_HUMAN) is depicted in the top panel. aa amino acids. B Confocal microscopic images of HEK293 cells transiently transfected with each of the constructs. The corresponding localization of the SEC23B protein is summarized in A. The predicted NES overlaps with the predicted NLS1 sequence. Scale bars, 8 μm.
