Fig. 3: Circ‐HMGA2 promotes the metastasis of LUAD cells in vitro. | Cell Death & Disease

Fig. 3: Circ‐HMGA2 promotes the metastasis of LUAD cells in vitro.

From: Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis

Fig. 3

A The expression of circ-HMGA2 in H1299 and A549 cell lines was significantly reduced after transfection with siRNA. B, C The results of transwell assays showed that the metastatic ability of H1299 and A549 cells was decreased after the circ‐HMGA2 knockdown. Scale bar: 200 μm. D The results of wound healing experiments showed that the migration of H1299 and A549 cells was decreased after circ‐HMGA2. Scale bar: 200 μm. E Circ-HMGA2 was significantly overexpressed in H1299 and A549 cells. F, G The metastatic ability was increased when the expression of circ-HMGA2 was enhanced. Scale bar: 200 μm. H Circ-HMGA2 had a promotive effect on EMT. *P < 0.05, **P < 0.01.

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