Fig. 7: The working model of Grail in the regulation of hepatic steatosis.
From: E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition
Grail expression is increased in hepatocytes with high-fat diet feeding. Grail interacts with sirtuin 1 (Sirt1) and subsequently degrades it by ubiquitination. This results in increased fatty acid uptake and synthesis and decreased beta-oxidation of fatty acid, thereby, synergistically aggravating fatty acid accumulation and hepatic steatosis.
