Fig. 4: FTO overexpression alleviates the IRI-impaired cell viability and attenuates mitochondrial fragmentation. | Cell Death & Disease

Fig. 4: FTO overexpression alleviates the IRI-impaired cell viability and attenuates mitochondrial fragmentation.

From: N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation

Fig. 4

A Cell viability in the hepatocytes infected with control AAV8-TBG-null and AAV8-TBG-FTO during IRI was detected by CCK-8 assays. B The total level of methylated RNA (m6A) in hepatocytes was detected by EpiQuik m6A RNA Methylation Quantification Kit. C Confocal microscopy was used to analyze the elongated, intermediate, fragmented mitochondria of cardiomyocytes infected with control AAV8-TBG-null and AAV8-TBG-FTO during IRI. N = 3; *P < 0.05 and ***P < 0.001 vs. AAV8-TBG-NC group.

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