Fig. 5: TCF4 interacted with ADCK1. | Cell Death & Disease

Fig. 5: TCF4 interacted with ADCK1.

From: ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells

Fig. 5

A A GST pulldown assay was performed to examine the interaction between ADCK1 and the GST-TCF4 fusion protein in SW620 and RKO cells. B Co-IP was performed to examine the interaction between exogenously expressed ADCK1 and TCF4 in SW620 cells. C Co-IP was performed to examine the interaction between endogenously expressed ADCK1 and TCF4 in SW620 cells. D Co-IP was performed to examine the effects of ADCK1 overexpression on the interaction between β-catenin and TCF4 in SW620 cells. E Co-IP was performed to examine the effects of ADCK1 knockdown on the interaction between β-catenin and TCF4 in SW620 cells. F Survival analysis according to ADCK1 expression for the cohort with low β-catenin expression. The ADCK1 high expression group (high) had poorer survival than the ADCK1 low expression group (low).

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