Fig. 1: HOTAIR and DNMT1 expression are raised, and PTEN is reduced in bone marrow of CML patients, and overexpression of HOTAIR is related to poor prognosis of CML patients. | Cell Death & Disease

Fig. 1: HOTAIR and DNMT1 expression are raised, and PTEN is reduced in bone marrow of CML patients, and overexpression of HOTAIR is related to poor prognosis of CML patients.

From: Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation

Fig. 1

A Expression of HOTAIR in patients with CML. B Expression of methyltransferase in patients with CML. C Expression of DNMT1 and PTEN mRNA in patients with CML. D Protein bands of DNMT1 and PTEN in patients with CML. E DNMT1 and PTEN protein expression levels in CML patients. F PTEN methylation in CML patients. G Effect of WHO classification on HOTAIR expression. H Effect of gender on HOTAIR expression. I Effect of age on HOTAIR expression (control group, n = 34; CML group, n = 47; CP group, n = 14; Ap group, n = 17; BC group, n = 16; male group, n = 25; Female group, n = 22; <47 y group, n = 24; >47 y group, n = 23). Measurement data were depicted as mean ± standard deviation, comparisons between two groups were conducted by independent sample t-test.

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