Fig. 2: HOTAIR and DNMT1 expression are elevated, and PTEN is reduced in CML cells. | Cell Death & Disease

Fig. 2: HOTAIR and DNMT1 expression are elevated, and PTEN is reduced in CML cells.

From: Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation

Fig. 2

A HOTAIR expression in CML cell lines in each group. B DNMT1 and PTEN mRNA expressions in CML cell lines in each group. C Protein bands of DNMT1 and PTEN in CML cell lines. D DNMT1 and PTEN protein expression in CML cell lines in each group. E HOTAIR expression in each group of K562 cells. F DNMT1 and PTEN mRNA expressions in each group of K562 cells. G Protein bands of DNMT1 and PTEN in each group of K562 cells. H DNMT1 and PTEN protein expression in each group of K562 cells. I HOTAIR expression in each group of KCL-22 cells. J DNMT1 and PTEN mRNA expressions in each group of KCL-22 cells. K Protein bands of DNMT1 and PTEN in each group of KCL-22 cells. L DNMT1 and PTEN protein expression in each group of KCL-22 cells. In CML cell lines, *P < 0.05 vs. the BMCs. In K562 cells, *P < 0.05 vs. the sh-NC group, #P < 0.05 vs. the si-NC group. In KCL-22 cells, *P < 0.05 vs. the pc-NC group, #P < 0.05 vs. the OE-NC group. N = 3. Measurement data were depicted as mean ± standard deviation. Comparisons among multiple groups were assessed by one-way ANOVA followed by Tukey’s multiple comparisons test.

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