Fig. 3: Downregulated HOTAIR or DNMT1 reduces the proliferation, colony formation and cell cycle progression, as well as increases apoptosis rate of CML cells. | Cell Death & Disease

Fig. 3: Downregulated HOTAIR or DNMT1 reduces the proliferation, colony formation and cell cycle progression, as well as increases apoptosis rate of CML cells.

From: Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation

Fig. 3

A K562 cell proliferation activity in each group. B KCL-22 cell proliferation activity in each group. C Colony formation of K562 cells in each group. D Number of colonies of K562 cells in each group. E Colony formation of KCL-22 cells in each group. F Number of colonies of KCL-22 cells in each group. G Cell cycle of K562 cells in each group. H K562 cell cycle ratio in each group. I Cell cycle of KCL-22 cells in each group. J KCL-22 cell cycle ratio in each group. K Apoptosis of K562 cells in each group. L Apoptosis rate of K562 cells in each group. M Apoptosis of KCL-22 cells in each group. N Apoptosis rate of KCL-22 cells in each group. In K562 cells, *P < 0.05 vs. the sh-NC group, #P < 0.05 vs. the si-NC group. In KCL-22 cells, *P < 0.05 vs. the pc-NC group, #P < 0.05 vs. the OE-NC group. N = 3. Measurement data were depicted as mean ± standard deviation. Comparisons among multiple groups were assessed by one-way ANOVA followed by Tukey’s multiple comparisons test.

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