Fig. 4: LDHA promotes the proliferation and inhibits the apoptosis of PTC cells in vitro and in vivo. | Cell Death & Disease

Fig. 4: LDHA promotes the proliferation and inhibits the apoptosis of PTC cells in vitro and in vivo.

From: LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma

Fig. 4

A–C CCK-8 assays and D–F colony formation assays showed that LDHA knockdown or inhibition significantly suppressed cell proliferation in B-CPAP cells and that the overexpression of LDHA promoted cell proliferation in KTC-1 cells. G, H Flow cytometry indicated that LDHA knockdown or inhibition significantly induced cell apoptosis in B-CPAP cells. I Five representative tumors from LDHA knockdown cells are shown. Tumor volumes J are presented with growth curves, and tumor weights K were measured. L Representative IHC images of cleaved caspase 3 expression and Ki-67 staining in xenografted tumor specimens of control and LDHA knockdown mice are shown. The data are presented as the mean ± SD. All *p < 0.05, **p < 0.01, ***p < 0.001.

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