Fig. 5: Discovery of LDHA regulated genes in PTC. | Cell Death & Disease

Fig. 5: Discovery of LDHA regulated genes in PTC.

From: LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma

Fig. 5

A Volcano plot of the gene expression changes that occurred after LDHA knockdown in B-CPAP cells assayed by RNA-Seq. B Summary of the significantly enriched pathways in B-CPAP cells after LDHA knockdown. C Heatmap from the RNA-Seq data showing the differentially expressed genes involved in the EMT process. D qPCR analysis of representative genes related to the EMT process after LDHA knockdown. The expression data were normalized to that of Actin in GFP knockdown cells. E Heatmap of the RNA-Seq data show that the differentially expressed genes were related to the mitochondrial respiratory chain complex. F qPCR analysis of representative genes related to the mitochondrial respiratory chain complex after LDHA knockdown. All *p < 0.05, **p < 0.01, ***p < 0.001.

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