Fig. 8: Schematic summary. | Cell Death & Disease

Fig. 8: Schematic summary.

From: RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis

Fig. 8

Active RANK expression allows for Ca2+ release from ER dependent on PLCĪ³-mediated IP3R and Ca2+ influx from the extracellular milieu through STIM1-regulated SOCE. Besides, PLCĪ³-mediated IP3R axis act upstream of STIM1 to coactivate Ca2+ oscillation. The Ca2+ oscillation in the cytoplasm leads to calcium-dependent calcineurin activation and NFATC1 transcription of osteoclast-specific gene, ACP5, which promotes CRC metastasis. PLCĪ³ phospholipase C Ī³, IP3R inositol-1,4,5-trisphosphate receptor, SOCE store-operated calcium entry, STIM stromal interaction molecule, TRPC transient receptor potential channel, NFATC1 nuclear factor of activated T cells c1, CsA cyclosporine A, 2APB 2-aminoethoxydiphenyl-borate, ACP5 tartrate-resistant acid phosphatase 5, ER endoplasmic reticulum.

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